Reduce Norovirus Burden
Human noroviruses are a large family of viruses and are leading causes of acute gastroenteritis (AGE) in all age groups worldwide. They have replaced rotavirus as the most common causes of AGE in children. Our research team is committed to studying molecular epidemiology and pathogenesis of human noroviruses. We have been working on monitoring emergence of novel strains. This will form scientific foundation for vaccine strain selection in the region. We are also working on teasing out host factors important for norovirus replication using intestinal organoids as models. This will better our understanding on disease-causing mechanism of noroviruses with insights into developing antiviral drug intervention to ultimately reduce norovirus burden.

Norovirus Activity in Hong Kong

February 2020 (week 9: 23rd – 29th) 

Research Team

Dr. Martin Chan, PhD
EducatPicture1ion and Training:
1. PhD (Medical Sciences), Chinese University of Hong Kong
2. MPhil (Biochemistry), Chinese University of Hong Kong
3. BSc (Molecular Biotechnology), Chinese University of Hong Kong
Research Interests:
1. Norovirus molecular epidemiology and pathogenesis
2. Novel virus discovery
3. Gut virome
4. Food virology
Linkedin   |   Publons  |   ORCiD  |  Google Scholar

Lau Sin Leung     Research Staff (2019-2020)

Miko Zhang     
Research Staff (2017-2020)

Erin Tse
Postdoctoral Fellow (2019-2020)

Jenny Chan
   MPhil (2017-2020) Current: Technical Officer, School of Public Health, Li Ka Shing Faculty of Medicine, University of Hong Kong [Linkedin]

Kirran Mohammad
    Research Staff (2017-2019)

Kirsty Kwok
Research Staff + MPhil (2015-2018) Current: Research Assistant, Centre for Virus Research, University of Glasgow, UK [Linkedin | Google Scholar]

Shelley Chan
    Research Staff (2016-2017)

Thomas Hung
    Research Staff (2015-2017)

Recent Publications

[New in 2022] Return of norovirus and rotavirus activity in winter 2020-21 in city with strict COVID-19 control strategy, China
Chan MC.
Emerg Infect Dis.  2022 Mar;28(3):713-716. [PubMed] [Publisher | Free]
Global trends in norovirus genotype distribution among children with acute gastroenteritis
Cannon JL, Bonifacio J, Bucardo F, Buesa J, Bruggink L, Chan MC, Fumian TM, Giri S, Gonzalez MD, Hewitt J, Lin JH, Mans J, Munoz C, Pan CY, Pang XL, Pietsch C, Rahman M, Sakon N, Selvarangan R, Browne H, Barclay L, Vinje J.
Emerg Infect Dis.  2021 May;27(5):1438-1445. [PubMed] [Publisher | Free]
Targeted profiling of immunological genes during norovirus replication in human intestinal enteroids
Chan JC, Mohammad KN, Zhang LY, Wong SH, Chan MC.
Viruses.  2021 Jan;13(2):155. [PubMed] [Publisher | Free]
Detection of norovirus variant GII.4 Hong Kong in Asia and Europe, 2017-2019
Chan MC, Roy S, Bonifacio J, Zhang LY, Chhabra P, Chan JC, Celma C, Igoy MA, Lau SL, Mohammad KN, Vinjé J, Vennema H, Breuer J, Koopmans M, de Graaf M, for NOROPATROL.
Emerg Infect Dis.  2021 Jan;27(1):289-293. [PubMed] [Publisher | Free]
Genome sequence of a human norovirus GII.4 Hong Kong[P31] variant in Hong Kong, China
Tse EH, Zhang LY, Lau SL, Chan MC.
Microbiol Resour Announc. 2020 Jan 16;9(3). pii: e01391-19. [PubMed] [Publisher | Free]
Updated classification of norovirus genogroups and genotypes
Chhabra P, de Graaf M, Parra GI, Chan MC, Green K, Martella V, Wang Q, White PA, Katayama K, Vennema H, Koopmans MPG, Vinjé J.
J Gen Virol. 2019 Oct;100(10):1393-1406. [PubMed] [Publisher] [Authors’ Copy]
Use of human intestinal enteroids to detect human norovirus infectivity
Chan MC, Cheung SK, Mohammad KN, Chan JC, Estes MK, Chan PK.
Emerg Infect Dis. 2019 Sep;25(9):1730-1733. [PubMed] [Publisher | Free]
Higher viral load of emerging norovirus GII.P16-GII.2 than pandemic GII.4 and epidemic GII.17, Hong Kong, China
Cheung SK, Kwok K, Zhang LY, Mohammad KN, Lui GC, Lee Nelson, Nelson EA, Lai RW, Leung TF, Chan PK, Chan MC.
Emerg Infect Dis. 2019 Jan;25(1):119-122. [PubMed] [Publisher | Free]
Bimodal seasonality and alternating predominance of norovirus GII.4 and non-GII.4, Hong Kong, China, 2014-2017
Chan MC, Kwok K, Zhang LY, Mohammad KN, Lee N, Lui GC, Nelson EA, Lai RW, Leung TF, Chan PK.
Emerg Infect Dis. 2018 Apr;24(4):767-769. [PubMed] [Publisher | Free]
Molecular surveillance of norovirus, 2005-16: an epidemiological analysis of data collected from the NoroNet network
van Beek J, de Graaf M, Al-Hello H, Allen DJ, Ambert-Balay K, Botteldoorn N, Brytting M, Buesa J, Cabrerizo M, Chan MCloak F, Bartolo ID, Guix S, Hewitt J, Iritani N, Jin M, Johne R, Lederer I, Mans J, Martella V, Maunula L, McAllister G, Niendorf S, Niesters HG, Podkolzin AT, Poljsak-Prijatelj M, Rasmussen LD, Reuter G, Tuite G, Kroneman A, Vennema H, Koopmans MP; NoroNet.
Lancet Infect Dis. 2018 May;18(5):545-553. [PubMed] [Publisher]
Increased detection of emergent recombinant norovirus GII.P16-GII.2 strains in young adults, Hong Kong, China, 2016-2017
Kwok K, Niendorf S, Lee N, Hung TN, Chan LY, Jacobsen S, Nelson EA, Leung TF, Lai RW, Chan PK, Chan MC.
Emerg Infect Dis. 2017 Nov;23(11):1852-1855. [PubMed] [Publisher | Free]
Global spread of norovirus GII.17 Kawasaki 308, 2014-2016
Chan MC, Hu Y, Chen H, Podkolzin AT, Zaytseva EV, Komano J, Sakon N, Poovorawan Y, Vongpunsawad S, Thanusuwannasak T, Hewitt J, Croucher D, Collins N, Vinjé J, Pang XL, Lee BE, de Graaf M, van Beek J, Vennema H, Koopmans MP, Niendorf S, Poljsak-Prijatelj M, Steyer A, White PA, Lun JH, Mans J, Hung TN, Kwok K, Cheung K, Lee N, Chan PK.
Emerg Infect Dis. 2017 Aug;23(8):1350-1354. [PubMed] [Publisher | Free]
Complete genome sequence of an emergent recombinant GII.P16-GII.2 norovirus strain associated with an epidemic spread in the winter of 2016-2017 in Hong Kong, China
Chan MC, Kwok K, Hung TN, Chan LY, Chan PK.
Genome Announc. 2017 May 18;5(20). pii: e00343-17. [PubMed] [Publisher | Free]
Letter to the Editor: Recurrent infections of emergent norovirus GII.17 in an elderly patient
Chan MC, Lee N, Hung TN, Chan LY, Kwok K, Wong RY, Chan PK.
Clin Infect Dis. 2017 Mar;64(5):697-679. [PubMed] [Publisher]
Rapid emergence and predominance of a broadly recognizing and fast-evolving norovirus GII.17 variant in late 2014
Chan MC, Lee N, Hung TN, Kwok K, Cheung K, Tin EK, Lai RW, Nelson EA, Leung TF, Chan PK.
Nat Commun. 2015 Dec 2;6:10061. [PubMed] [Publisher | Free]
Virus genotype distribution and virus burden in children and adults hospitalized for norovirus gastroenteritis, 2012-2014, Hong Kong
Chan MC, Leung TF, Chung TW, Kwok AK, Nelson EA, Lee N, Chan PK.
Sci Rep. 2015 Jun 17;5:11507. [PubMed] [Publisher | Free]
Chan MC and Chan JC. (2019). Human organoids: past, present, and future. In A. Chan (Ed.), Biotechnology in Hong Kong Volume IV (pp. 15-27). New York: United States-China Intellectual Property Institute Inc.
 [Book Chapter | Free][Whole Book | Free]
Chan MC et al. (2017). Structure and genotypes of noroviruses. In P. Chan, H-S. Kwan, & M. Chan (Eds.), The Norovirus: Features, Detection, and Prevention of Foodborne Disease (pp. 51-63). Netherlands: Elsevier. [Elsevier Store]