Human noroviruses are a large family of viruses and are leading causes of acute gastroenteritis (AGE) in all age groups worldwide. They have replaced rotavirus as the most common causes of AGE in children. Our research team is committed to studying molecular epidemiology and pathogenesis of human noroviruses. We have established a surveillance system in hospitalized AGE cases in Hong Kong to untangle norovirus genotype distribution among children and adults and to monitor emergence of novel strains. This will form scientific foundation for vaccine strain selection in the region. We are also working on teasing out host interactome of norovirus structural proteins. This will better our understanding on disease-causing mechanism of noroviruses with insights into antiviral drug intervention.
Available research projects: (1) Molecular surveillance of norovirus; (2) Mechanism of new norovirus emergence; (3) Norovirus gastroenteritis and gut virome; and (4) Metagenomic NGS in clinical diagnosis of acute infections.
Norovirus Activity in Hong Kong
February 2020 (week 7: 9th – 15th)
Dr. Martin Chan, PhD
Team Leader | Assistant Professor
Education and Training: 1. PhD (Medical Sciences), Chinese University of Hong Kong
2. MPhil (Biochemistry), Chinese University of Hong Kong
3. BSc (Molecular Biotechnology), Chinese University of Hong Kong
Research Interests: 1. Norovirus molecular epidemiology and pathogenesis 2. Novel virus discovery 3. Gut virome 4. Food virology
After completing my PhD in Biomedical Sciences at Aston University, I became interested in the use of stem-cell derived models to study disease pathology. I am primarily trained in mammalian cell culture and molecular biology techniques. My current research interests lie in the use of molecular techniques to help screen for host factors involved in mediating norovirus infection in a human enteroid model.
MPhil Research Student
I obtained my BSc (Hons) in Virology from the University of Glasgow, where I was fascinated by molecular virology, in particular the approaches employed by different viruses to cause diseases. My current project is to identify potential host factors benefiting norovirus infection utilising the enteroid model.
Lau Sin Leung
Kirran Mohammad Research Staff (2017-2019)
Kirsty Kwok Research staff + MPhil (2015-2018) Current: PhD Candidate, Viroscience, Erasmus MC, the Netherlands
Shelley Chan Research Staff (2016-2017)
Thomas Hung Research Staff (2015-2017)
[New in 2020] Genome sequence of a human norovirus GII.4 Hong Kong[P31] variant in Hong Kong, China Tse EH, Zhang LY, Lau SL, Chan MC. Microbiol Resour Announc.2020 Jan 16;9(3). pii: e01391-19. [Publisher | Free]
Updated classification of norovirus genogroups and genotypes Chhabra P, de Graaf M, Parra GI, Chan MC, Green K, Martella V, Wang Q, White PA, Katayama K, Vennema H, Koopmans MPG, Vinjé J. J Gen Virol.2019 Oct;100(10):1393-1406. [PubMed] [Publisher] [Authors’ Copy]
Use of human intestinal enteroids to detect human norovirus infectivity Chan MC, Cheung SK, Mohammad KN, Chan JC, Estes MK, Chan PK. Emerg Infect Dis.2019 Sep;25(9):1730-1733. [PubMed] [Publisher | Free]
Higher viral load of emerging norovirus GII.P16-GII.2 than pandemic GII.4 and epidemic GII.17, Hong Kong, China Cheung SK, Kwok K, Zhang LY, Mohammad KN, Lui GC, Lee Nelson, Nelson EA, Lai RW, Leung TF, Chan PK, Chan MC. Emerg Infect Dis.2019 Jan;25(1):119-122. [PubMed] [Publisher | Free]
Bimodal seasonality and alternating predominance of norovirus GII.4 and non-GII.4, Hong Kong, China, 2014-2017 Chan MC, Kwok K, Zhang LY, Mohammad KN, Lee N, Lui GC, Nelson EA, Lai RW, Leung TF, Chan PK. Emerg Infect Dis.2018 Apr;24(4):767-769. [PubMed] [Publisher | Free]
Molecular surveillance of norovirus, 2005-16: an epidemiological analysis of data collected from the NoroNet network van Beek J, de Graaf M, Al-Hello H, Allen DJ, Ambert-Balay K, Botteldoorn N, Brytting M, Buesa J, Cabrerizo M, Chan M, Cloak F, Bartolo ID, Guix S, Hewitt J, Iritani N, Jin M, Johne R, Lederer I, Mans J, Martella V, Maunula L, McAllister G, Niendorf S, Niesters HG, Podkolzin AT, Poljsak-Prijatelj M, Rasmussen LD, Reuter G, Tuite G, Kroneman A, Vennema H, Koopmans MP; NoroNet. Lancet Infect Dis.2018 May;18(5):545-553.[PubMed][Publisher]
Increased detection of emergent recombinant norovirus GII.P16-GII.2 strains in young adults, Hong Kong, China, 2016-2017 Kwok K, Niendorf S, Lee N, Hung TN, Chan LY, Jacobsen S, Nelson EA, Leung TF, Lai RW, Chan PK, Chan MC. Emerg Infect Dis.2017 Nov;23(11):1852-1855. [PubMed] [Publisher | Free]
Global spread of norovirus GII.17 Kawasaki 308, 2014-2016 Chan MC, Hu Y, Chen H, Podkolzin AT, Zaytseva EV, Komano J, Sakon N, Poovorawan Y, Vongpunsawad S, Thanusuwannasak T, Hewitt J, Croucher D, Collins N, Vinjé J, Pang XL, Lee BE, de Graaf M, van Beek J, Vennema H, Koopmans MP, Niendorf S, Poljsak-Prijatelj M, Steyer A, White PA, Lun JH, Mans J, Hung TN, Kwok K, Cheung K, Lee N, Chan PK. Emerg Infect Dis.2017 Aug;23(8):1350-1354. [PubMed] [Publisher | Free]
Complete genome sequence of an emergent recombinant GII.P16-GII.2 norovirus strain associated with an epidemic spread in the winter of 2016-2017 in Hong Kong, China Chan MC, Kwok K, Hung TN, Chan LY, Chan PK. Genome Announc. 2017 May 18;5(20). pii: e00343-17. [PubMed] [Publisher | Free]
Letter to the Editor: Recurrent infections of emergent norovirus GII.17 in an elderly patient Chan MC, Lee N, Hung TN, Chan LY, Kwok K, Wong RY, Chan PK. Clin Infect Dis. 2017 Mar;64(5):697-679. [PubMed] [Publisher]
Rapid emergence and predominance of a broadly recognizing and fast-evolving norovirus GII.17 variant in late 2014
Chan MC, Lee N, Hung TN, Kwok K, Cheung K, Tin EK, Lai RW, Nelson EA, Leung TF, Chan PK. Nat Commun. 2015 Dec 2;6:10061. [PubMed] [Publisher | Free]
Virus genotype distribution and virus burden in children and adults hospitalized for norovirus gastroenteritis, 2012-2014, Hong Kong
Chan MC, Leung TF, Chung TW, Kwok AK, Nelson EA, Lee N, Chan PK. Sci Rep.2015 Jun 17;5:11507.[PubMed] [Publisher | Free]
BOOK CHAPTERS [NEW]Chan MC and Chan JC. (2019). Human organoids: past, present, and future. In A. Chan (Ed.), Biotechnology in Hong Kong Volume IV (pp. 15-27). New York: United States-China Intellectual Property Institute Inc.[Book Chapter | Free][Whole Book | Free]
Chan MC et al. (2017). Structure and genotypes of noroviruses. In P. Chan, H-S. Kwan, & M. Chan (Eds.), The Norovirus: Features, Detection, and Prevention of Foodborne Disease (pp. 51-63). Netherlands: Elsevier.[Elsevier Store]
Research Opportunities – Join Us!
PROSPECTIVE MPHIL AND PHD STUDENTS
We are always looking for talented young researchers to join our team. Space is limited. If one is interested in our projects on norovirus, please contact us (firstname.lastname@example.org) as far in advance as possible. Online application closes in late January every year and research study starts in August. We can offer suitable candidate a short-term research post prior to the study.
Available Research Projects: 1. Molecular surveillance of norovirus; 2. Mechanism of new norovirus emergence; 3. Norovirus gastroenteritis and gut virome; and 4. Metagenomic NGS in clinical diagnosis of acute infections